ASTM E3302-22
Standard Guide for PFAS Analytical Methods Selection

Standard No.

ASTM E3302-22

Release Date

2022

Published By

American Society for Testing and Materials (ASTM)

Status

Be replaced 2023-12

Replace By

ASTM E3302-23

Latest

ASTM E3302-23

Scope

1.1 This guide discusses the selection and application of analytical methods and techniques used to identify and quantitate perand polyfluoroalkyl substances (PFAS) in environmental media. This guide provides a flexible, defensible framework applicable to a wide range of environment programs. It is structured to support a tiered approach with analytical methods, procedures, and techniques of increasing complexity as the user proceeds through the evaluation process. This guide addresses key decision criteria and best practices to aid users in achieving project objectives. There are numerous technical decisions that must be made in the selection and application of analytical methods and techniques used during environmental data acquisition programs. It is not the intent of this guide to define appropriate technical decisions, but rather to provide technical support within existing decision frameworks. 1.2 This guide informs practitioners on the considerations relevant to the selection and application of analytical methods and techniques for the quantitative and qualitative determination of PFAS in a variety of environmental sample media. This guide encourages user-led collaboration with stakeholders, including analytical laboratories, data evaluation practitioners, and regulators, in the selection and application of analytical methods and techniques used to support project-specific decision criteria and objectives as applied within a particular environmental regulatory program. This guide recognizes the complexity and diversity of environmental programs and project objectives and provides technical support for a range of project applications. 1.3 This guide is intended to complement, not replace, existing regulatory requirements or guidance. ASTM International (ASTM) guides are not regulations; they are consensusbased standards that may be followed as needed. 1.4 This guide recognizes that PFAS can be categorized as polymeric or nonpolymeric, collectively amounting to more than 4 700 Chemical Abstracts Service (CAS)-registered substances. Environmental concerns pertaining to PFAS are centered primarily on the perfluoroalkyl acids (PFAA), a subclass of PFAS, which display extreme persistence and chain-lengthdependent bioaccumulation and adverse effects in biota. 1.5 This guide recognizes that published analytical methods performed by commercial laboratories are limited to determination of a small subset of the more than 4 700 CAS-registered PFAS. 1.6 The goal of this guide is to provide a technical framework for informed selection and application of analytical methods and techniques for the determination of target and non-target PFAS in environmental sample media. 1.7 This guide aids users in selecting PFAS analytical methods for various environmental applications. 1.8 This guide discusses existing published analytical methods for quantitative determination of method-specific lists of target analytes, as well as non-standard analytical approaches developed to qualitatively determine a broader range of PFAS, for a variety of environmental applications. This guide also provides an overview of research trends in this rapidly developing field. 1.9 This guide discusses the challenges and limitations of analytical methods and techniques in the detection and quantitation of the large, complex set of PFAS. 1.10 This guide describes widely accepted considerations and best practices used in the selection and application of analytical procedures used during PFAS environmental programs. This guide complements but does not replace existing technical guidance and regulatory requirements. 1.11 Units—The values stated in SI units are to be regarded as the standard. 1.11.1 Other units, such as fractional units of parts per billion and parts per trillion, are also included in this guide. 1.12 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use. 1.13 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the 1 This guide is under the jurisdiction of ASTM Committee E50 on Environmental Assessment, Risk Management and Corrective Action and is the direct responsibility of Subcommittee E50.04 on Corrective Action. Current edition approved July 1, 2022. Published July 2022. Originally published in 2021. Last previous edition approved in 2021 as E3302–21. DOI: 10.1520/ E3302–22 Copyright © ASTM International, 100 Barr Harbor Drive, PO Box C700, West Conshohocken, PA 19428-2959. United States This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee. 1 Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.

ASTM E3302-22 Referenced Document

• ASTM D7968 Standard Test Method for Determination of Polyfluorinated Compounds in Soil by Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS)*， 2023-11-01 Update
• ASTM D7979 Standard Test Method for Determination of Per- and Polyfluoroalkyl Substances in Water, Sludge, Influent, Effluent, and Wastewater by Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS)
• ASTM D8421 Standard Test Method for Determination of Per- and Polyfluoroalkyl Substances (PFAS) in Aqueous Matrices by Co-solvation followed by Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS)
• ISO 21675 Water quality — Determination of perfluoroalkyl and polyfluoroalkyl substances (PFAS) in water — Method using solid phase extraction and liquid chromatography-tandem mass spectrometry (LC-MS/MS)
• ISO 25101 Water quality - Determination of perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) - Method for unfiltered samples using solid phase extraction and liquid chromatography/mass spectrometry

ASTM E3302-22 history

• 2023 ASTM E3302-23 Standard Guide for PFAS Analytical Methods Selection
• 2022 ASTM E3302-22 Standard Guide for PFAS Analytical Methods Selection
• 2021 ASTM E3302-21 Standard Guide for PFAS Analytical Methods Selection