ISO 19290:2021
Cigarettes - Determination of tobacco specific nitrosamines in mainstream cigarette smoke - Method using LC-MS/MS

Standard No.

ISO 19290:2021

Release Date

2021

Published By

International Organization for Standardization (ISO)

Latest

ISO 19290:2021

Scope

This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in the total particulate matter of mainstream cigarette smoke by using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS). The quantified TSNAs are: N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

ISO 19290:2021 Referenced Document

• ISO 3308 Routine analytical cigarette-smoking machine - Definitions and standard conditions
• ISO 3402 Tobacco and tobacco products — Atmosphere for conditioning and testing*， 2023-01-30 Update
• ISO 4387 Cigarettes — Determination of total and nicotine-free dry particulate matter using a routine analytical smoking machine
• ISO 8243 Cigarettes.Sampling

ISO 19290:2021 history

• 2021 ISO 19290:2021 Cigarettes - Determination of tobacco specific nitrosamines in mainstream cigarette smoke - Method using LC-MS/MS
• 2016 ISO 19290:2016 Cigarettes - Determination of tobacco specific nitrosamines in mainstream cigarette smoke - Method using LC-MS/MS