ASTM F720-81(2007)e1
Standard Practice for Testing Guinea Pigs for Contact Allergens: Guinea Pig Maximization Test

Standard No.

ASTM F720-81(2007)e1

Release Date

1981

Published By

American Society for Testing and Materials (ASTM)

Status

Be replaced

Replace By

ASTM F720-81(2012)

Latest

ASTM F720-17

Scope

In selecting a new material for human contact in medical applications, it is important to ensure that the material will not stimulate the immune system to produce an allergic reaction. The reaction would be due to substances which could leach out of a material. Therefore, this practice provides for using material extracts. The rationale for this practice is based on the fact that the guinea pig has been shown to be the best animal model for human allergic contact dermatitis. The use of Freundrsquo;complete adjuvant and sodium lauryl sulfate tends to enhance the potential of a material to cause an allergy. Therefore, this test, while not guaranteeing that a material is nonallergenic, is the most severe animal test in common use today.

1.1 This practice is intended to determine the potential for a substance, or material extract, to elicit contact dermal allergenicity.

1.2 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

ASTM F720-81(2007)e1 Referenced Document

• ASTM F619 Standard Practice for Extraction of Medical Plastics

ASTM F720-81(2007)e1 history

• 2017 ASTM F720-17 Standard Practice for Testing Guinea Pigs for Contact Allergens: Guinea Pig Maximization Test
• 2013 ASTM F720-13 Standard Practice for Testing Guinea Pigs for Contact Allergens: Guinea Pig Maximization Test
• 1981 ASTM F720-81(2012) Standard Practice for Testing Guinea Pigs for Contact Allergens: Guinea Pig Maximization Test
• 1981 ASTM F720-81(2007)e1 Standard Practice for Testing Guinea Pigs for Contact Allergens: Guinea Pig Maximization Test
• 1981 ASTM F720-81(2007) Standard Practice for Testing Guinea Pigs for Contact Allergens: Guinea Pig Maximization Test
• 1981 ASTM F720-81(2002)e1 Standard Practice for Testing Guinea Pigs for Contact Allergens Guinea Pig Maximization Test