ISO 15819:2008 Cosmetics - Analytical methods - Nitrosamines: Detection and determination of N-nitrosodiethanolamine (NDELA) in cosmetics by HPLC-MS-MS
This International Standard describes a method for the detection and quantification of NDELA in cosmetics
and raw materials used in cosmetics.
This method is not applicable to the detection and/or quantification of nitrosamines other than NDELA nor to
the detection and/or quantification of NDELA in products other than cosmetics or raw materials used in
cosmetics.
If a product has a possibility of either NDELA contamination from ingredients or NDELA formation by the
composition of ingredients, the method shall be applied for quantitative determination of NDELA. Accordingly
the method would not be applied in routine testing of cosmetic products. Because of the large variety of
cosmetic products within this field of application, this method might need to be adapted for certain matrices.
Therefore, International Standards dedicated to alternative methods for testing nitrosamines in cosmetic
products are being developed separately. Other methods can be employed provided that they are verified as
to their detection of NDELA and validated in terms of recovery and quantification of the analyte.
ISO 15819:2008 history
2014ISO 15819:2014 Cosmetics - Analytical methods - Nitrosamines: Detection and determination of N-nitrosodiethanolamine (NDELA) in cosmetics by HPLC-MS-MS
2008ISO 15819:2008 Cosmetics - Analytical methods - Nitrosamines: Detection and determination of N-nitrosodiethanolamine (NDELA) in cosmetics by HPLC-MS-MS