International Organization for Standardization (ISO)
Latest
ISO 13829:2000
Scope
This International Standard specifies a procedure which can be used to determine the genotoxicity of water and waste water using the umu-test.
This assay is based on the detection of genotoxicity of a test sample which increases the expression of the SOS-repair system associated with the umuC-gene.
note: 1) Toxicity which specifically affects the genome (genetic material).
2) SOS repair occurs when cells are overwhelmed by genotoxins allowing the cell to survive at the cost of mutagenesis.
3) umuC-gene is the acronym for UV mutagenesis gene C. The induction of the umuC-gene is part of the specific response of the bacterial cell to DNA-damage.
ISO 13829:2000 history
2000ISO 13829:2000 Water quality - Determination of the genotoxicity of water and waste water using the umu-test