ASTM D8442-22
Standard Test Method for Determination of Cannabinoids in Cannabis Raw Materials and Resin Cannabis Products by Gas Chromatography and Flame Ionization Detection

Standard No.

ASTM D8442-22

Release Date

2022

Published By

American Society for Testing and Materials (ASTM)

Latest

ASTM D8442-22

Scope

1.1 This test method covers the analysis of cannabinoids in cannabis products by gas chromatography (GC) and flame ionization detection (FID). 1.2 This test method is applicable to cannabis raw materials and resin cannabis products as defined in Guide D8245, including those from hemp. Such material includes: biomass; plant material; flowers; resins; extracts; distillates; recovered solvents; and other intermediate processing material. The applicable concentration range of analysis will vary to some extent depending on the nature of the sample, for instance measurement of delta-9-tetrahydrocannabinol (∆9 -THC) for regulatory purposes in hemp would require calibration to lower concentration levels compared to measurement of CBD in its isolate; however, in most cases, the test method is applicable to the determination of major and minor cannabinoids above about 0.1 mass% in concentration. Dilution of sample solutions is used to adjust concentrations to fall within appropriate calibration curves. Particular emphasis is placed on the determination of ∆9 -THC for regulatory compliance purposes and control. This test method can measure any cannabinoid that is eluted and detected from a GC column with sufficient resolution from any interfering compounds. Typical cannabinoids of interest that can be determined by this test method are shown in Table 1. Use of an HPLC technique is recommended if individual measurement of acids, such as THCA, is required. 1.3 The test method does not purport to identify all individual cannabinoids; however, individual users can adapt this test method for specific custom analyses to meet their needs. 1.4 Units—Values stated in SI units are to be regarded as the standard. No other units of measurement are included in this standard. 1.5 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use. 1.6 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.

ASTM D8442-22 Referenced Document

• ASTM D4307 Standard Practice for Preparation of Liquid Blends for Use as Analytical Standards
• ASTM D4626 Standard Practice for Calculation of Gas Chromatographic Response Factors
• ASTM D8245 Standard Guide for Disposal of Resin-Containing Cannabis Raw Materials and Downstream Products
• ASTM D8270 Standard Terminology Relating to Cannabis*， 2023-05-15 Update
• ASTM D8282 Standard Practice for Laboratory Test Method Validation and Method Development
• ASTM D8334/D8334M Standard Practice for Sampling of Cannabis/Hemp Post-Harvest Batches for Laboratory Analyses
• ASTM D8375 Standard Test Method for Determination of Cannabinoid Concentration in Dried Cannabis and Hemp Raw Materials using Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) (Standard + Redline PDF Bundle)*， 2023-03-30 Update
• ASTM E1510 Standard Practice for Installing Fused Silica Open Tubular Capillary Columns in Gas Chromatographs
• ASTM E355 Standard Practice for Gas Chromatography Terms and Relationships*， 2024-04-22 Update
• ASTM E594 Standard Practice for Testing Flame Ionization Detectors Used in Gas or Supercritical Fluid Chromatography

ASTM D8442-22 history

• 2022 ASTM D8442-22 Standard Test Method for Determination of Cannabinoids in Cannabis Raw Materials and Resin Cannabis Products by Gas Chromatography and Flame Ionization Detection