ASTM E2045-22 PDF

Scope: 1.1 This practice describes the terms used in observing and recording cutaneous, gastrointestinal, respiratory, reproductive, neuromuscular, ocular, and general clinical signs of animals undergoing toxicological testing. This practice also assists in properly observing and assessing laboratory animals for signs of disease or adverse effects of compound administration. 1.2 This practice includes codes and descriptions for a wide variety of clinical signs, anatomical locations, and other descriptive qualifiers, and a technique for scoring the extent or severity of clinical signs. 1.3 This practice assumes that the reader is knowledgeable in animal toxicology and related pertinent areas and is trained in making clinical observations. 1.4 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use. 1.5 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.

ASTM E2045-22 history

2022 ASTM E2045-22 Standard Practice for Detailed Clinical Observations of Test Animals
1999 ASTM E2045-99(2014) Standard Practice for Detailed Clinical Observations of Test Animals
1999 ASTM E2045-99(2009) Standard Practice for Detailed Clinical Observations of Test Animals
1999 ASTM E2045-99(2003) Standard Practice for Detailed Clinical Observations of Test Animals
1999 ASTM E2045-99 Standard Practice for Detailed Clinical Observations of Test Animals