API PUBL 32-32169-1985 ACUTE INHALATION TOXICITY EVALUATION OF A PETROLEUM DERIVED HYDROCARBON IN RATS API Sample 83-06 HEAVY CATALYTIC REFORMED NAPHTHA
ABSTRACT A petroleum-derived hydrocarbon mixture@ API No. 83-06@ was evaluated for its acute inhalation toxicity. Five young adult rats of each sex were exposed to a target vapor concentration of 5.0 milligrams/liter (mg/L) for 4 hours. Vapors were generated by a countercurrent distillation process and administered in the breathing air of the animals utilizing dynamic whole-body exposure methods. During pre-exposure atmosphere characterization tests@ API No. 83-06@ when generated using the above method@ produced an atmosphere that was entirely of vapors. Analysis of vapor concentrations was performed by continuously measuring total hydrocarbon content and yielded a time weighted average of 5.04 ?? 0.900 mg/L for API material. No animals died or exhibited clinical signs during the course of the exposures or during the 14 day observation period. Individual and mean body weights were not affected by exposure to the test material. Inflammatory lesions observed grossly and microscopically In the lungs of rats 14 days after exposure were of a type and intensity commonly observed In unexposed laboratory rats. The significance of the inhalation exposure@ if any@ in the generation of these lesions could not be established.
API PUBL 32-32169-1985 history
1985API PUBL 32-32169-1985 ACUTE INHALATION TOXICITY EVALUATION OF A PETROLEUM DERIVED HYDROCARBON IN RATS API Sample 83-06 HEAVY CATALYTIC REFORMED NAPHTHA